Covid hospitalisation, family history, lifestyle behaviours behind unexplained sudden death: ICMR study

By Admin

08 Jul, 2025

Understanding the Mystery of Sudden Deaths Among Young Adults

In recent years, India has witnessed a disturbing trend of sudden, unexplained deaths among seemingly healthy young adults. A groundbreaking study led by the Indian Council of Medical Research (ICMR), published in the Indian Journal of Medical Research, sheds light on the possible reasons behind these tragic occurrences, focusing on adults aged 18-45 years.

Study Overview and Objective

The peer-reviewed study, conducted in 2023, aimed to identify factors associated with unexplained sudden deaths among young Indian adults. It was prompted by anecdotal reports linking such deaths to Covid-19 infection or vaccination. To examine these associations scientifically, researchers utilized a multicentric matched case-control model involving 729 cases and 2,916 controls across 47 tertiary hospitals in India.

Key Findings from the ICMR Study

1. Covid-19 Vaccination Not a Risk Factor
   One of the most critical insights from the study is that Covid-19 vaccination did not increase the risk of unexplained sudden deaths in young adults. In fact, receiving one or more doses of the vaccine was associated with lower odds of such deaths. This finding helps dispel widespread misinformation around the safety of Covid-19 vaccines.
   
   

2. Major Risk Factors Identified
   The research highlighted several key contributors that did increase the risk:
   
   

• Past hospitalisation due to severe Covid-19 infection
  
  

• A family history of sudden or unexplained death
  
  

• Binge drinking within 48 hours before death
  
  

• Use of recreational drugs or substances
  
  

• Engaging in vigorous-intensity physical activity 48 hours prior to death
  
  

3. Population Studied
   The study focused on individuals aged 18-45 years who were reportedly healthy and had no known comorbidities. These individuals were alive and well within 24 hours of their death, making their sudden passing especially alarming.
   
   

4. Methodology
   Each case was matched with four controls based on age, gender, and neighborhood. Detailed interviews and medical records were used to analyze the subjects’ history with Covid-19, vaccination status, family medical background, substance use, and physical activity levels.
   
   

Implications of the Study

The ICMR study provides crucial data that can inform public health strategies and personal lifestyle decisions. It urges individuals to be cautious of high-risk behaviours, particularly in the post-Covid recovery phase. Moreover, the findings reinforce the safety and protective nature of Covid-19 vaccines.

Conclusion

While sudden deaths in young, healthy adults are deeply distressing, the ICMR’s study offers much-needed clarity. By identifying the real risk factors   Covid-19 hospitalisation, genetic predisposition, and specific lifestyle behaviours   this research paves the way for better awareness, prevention, and policy-making.

As India continues to recover from the pandemic, such studies are vital in guiding both individual choices and national healthcare planning.